Glucosamine Sulfate 2NaCl contains 20% sodium chloride as stabilizer, with sulfate groups directly involved in cartilage metabolism. Clinical studies show 15-20% higher bioavailability compared to hydrochloride, making it particularly suitable for joint maintenance in elderly populations. After dissociation, sulfate groups serve as essential substrates for glycosaminoglycan synthesis, while sodium ions help maintain normal synovial fluid osmotic pressure.